Clinical applications of stem cells
derived from Adipose tissue through trypsinless culture. ; Perspectives in
Korean Industry
Lee, Hee-young. M.D., Ph.D., BaroYl
plastic surgery, Medikan Inc., Seoul, Korea.
The effectiveness of stem cells
therapies is now regarded to be proportional to number of therapeutic cell.
Adipose tissues are the most
optimal source to get enough of number of stem cell in clinical trials.
However, culture expansion is still necessary to keep certain level of stem
cell densities in some periods for normal regeneration mechanism.
So, we have been used culture expansion
in many cases. We started cultured cell therapies in late 1999. Due to several
regulation law and new guidelines legislated at 2006, we had to restrict cell-culture
methods in ‘minimal manipulation’ which is not yet defined clearly so far.
We have been developed infinitive
trypsinless culture with minimal passages which we use air tight culture
vessels and magnetic cell scrapers to keep close to meet condition of 'minimal manipulation'
much as possible.
We can save time and cost a lot
especially in clinical trials with this method. Moreover, it could be developed
as an automatic culture system easier.
Most of all the merits, we could
say it is the safest type of stem cell culture. We would like to introduce this
new innovative method and clinical results of several wound healing cases such
as filler embolisms which we can see mechanism only with photos.
In this year,
Japan started a new policy to encourage the industry of stem cell therapies, so
Korean government is about to legislate a new law and regulation
in generative medicine as like as Japan.
But, whether the
new law would be made or not, our methods are concerned in the most minimal
manipulation culture within the boundary of legal therapies in Korea.
